Scholar Rock
Senior Scientist II, Upstream Process Development and MSAT
- Compensation
- $155K–$195K / yr
- Location
- Cambridge, MA, US
- Arrangement
- On-site
- Employment type
- Full-time
- Level
- Senior
- Posted
- 2 November 2026 (13 days ago)
Checked 12 days agoApplications go to the employer, never to RoleSprint
About this role
Scholar Rock is delivering muscle-targeted breakthroughs to transform the treatment of spinal muscular atrophy (SMA) and other rare neuromuscular diseases where muscle atrophy remains a critical unmet need. As a global leader in myostatin biology, a field focused on proteins that regulate muscle mass, the biopharmaceutical company is named for the visual resemblance of a scholar rock to protein structures. Our commitment to unlock fundamentally different treatment approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. Scholar Rock works every day to create new possibilities for patients through its highly innovative anti-myostatin program, including opportunities in additional rare neuromuscular diseases. Learn more about our neuromuscular franchise at ScholarRock.com and follow @ScholarRock on X and on LinkedIn.
Summary of Position:
Scholar Rock is delivering muscle-targeted breakthroughs to transform the treatment of spinal muscular atrophy (SMA) and other rare neuromuscular diseases where muscle atrophy remains a critical unmet need. As a global leader in myostatin biology, a field focused on proteins that regulate muscle mass, the biopharmaceutical company is named for the visual resemblance of a scholar rock to protein structures. Our commitment to unlock fundamentally different treatment approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. Scholar Rock works every day to create new possibilities for patients through its highly innovative anti-myostatin program, including opportunities in additional rare neuromuscular diseases. Learn more about our neuromuscular franchise at ScholarRock.com and follow @ScholarRock on X and on LinkedIn.
Summary of Position:
Position Responsibilities • Drive upstream process development activities for early- and late-stage biologics programs, including cell culture process experimental design, media and feed optimization, and bioreactor process characterization. Execute in-lab as needed and present data and recommendations to inform development direction to leadership. • Provide guidance for upstream scale-up, technology transfer, manufacturability assessments and validation activities across external manufacturing sites • Serve as a subject matter expert for external upstream process development activities, including collaborating with external CDMOs to design robust and technically sound experiments to progress Scholar Rock’s development pipeline • Serve as a subject matter expert for internal upstream process development activities. Collaborate cross-functionally with Research, Analytical Development, Quality, Regulatory Affairs, and Downstream Process Development teams to advance programs from early development through commercialization • Support research, downstream process development, and assay development as needed • Design experiments and draft protocols to support critical manufacturing deviations and investigations, including internal experimental execution and studies designed for external CMO execution; support the development and implementation of future internal high-throughput bioreactor capabilities, such as AMBR. • Review manufacturing documents and troubleshoot outsourced manufacturing processes as needed • Support clinical and commercial GMP manufacturing with person-in-plant activities • Author upstream technical reports to enable program stage progression and robust regulatory filing input
Candidate Requirements • Educational background in Chemical Engineering, Biochemistry, Biotechnology, or related biological Sciences • Experience in DOE, QBD development, process characterization and process validation exercises highly desired • Direct experience working with mAbs and CHO cell culture is preferred • BS or MS with 10+ years of experience, Ph.D. with 5+ years of experience • Experience with Ambr 15/250 high throughput cell culture desired • Experience with tech transfer to manufacturing preferred • Cell line development experience is a plus • Strong attention to detail and experience in summarizing and presenting results to leadership is required • Some travel required (person-in-plant)
Scholar Rock is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Work location
- Cambridge, MA, US
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About this listing
Published on Lever under the board identifier Scholarrock, which is the name the employer’s own job board carries. RoleSprint has not verified the company’s registered or trading name, so it is shown exactly as published rather than tidied up.
RoleSprint is not the employer and not a recruiter. Applications are made on the employer’s own site and never reach us; what RoleSprint does is help you decide whether a role is worth your time and prepare for it if it is.
Published 2 November 2026, last checked 12 days ago. A posting stops being advertised here 90 days after the employer published it, and one the employer takes down is marked closed rather than quietly removed.