E11 Bio - Research Associate, In Vivo

Responsibilities • Execute retro-orbital and stereotaxic viral injections, with post-operative monitoring

• Prepare perfusates and run perfusions to SOP standards, and keep perfusion and surgical setups operational

• Collect and process tissue, including sectioning of the fixed brain, histology and immunostaining, and imaging

• Run colony management and animal supply: breeding, weaning, genotyping workflows, health checks and record keeping

• Support perfusion development: run controlled perturbations and document QC outcomes

• Prepare equipment and supplies for experiments, keep the reagents and consumables for these workflows stocked, and flag supply problems early

• Work to approved animal protocols and comply with federal and institutional IACUC regulations governing animal research

• Keep accurate, reproducible experimental records

Outcomes In 1 month

• Completed training in retro-orbital and stereotaxic injections, and running routine surgeries with good survival and recovery

• Performing perfusions under supervision at the team's baseline quality level, with perfusates prepared independently

In 3 months

• Running the colony: health checks, weaning and genotyping workflows on schedule

• Trained on imaging and running it routinely

• Independently producing fixed tissue at baseline quality

In 6 months

• Carrying one small focused piece of development work, scoped with a scientist

Required qualifications • BS/BA in a STEM field with 0 to 4 years of relevant experience, or an MS, or equivalent hands-on experience

• Experience with rodent handling, restraint and procedures under an approved protocol, and willingness to work with small animals and animal tissue

• Strong lab notebook practice, careful experimental documentation and attention to detail

• Ability to work some weekends as needed, with days off swapped for weekdays

Preferred qualifications • Hands-on experience performing animal perfusions with PFA or related fixatives for brain tissue applications

• Experience with stereotaxic or retro-orbital viral injections, or clear interest and aptitude to train into them

• Experience with transgenic mouse colony management, including breeding and genotyping workflows

• Experience with histology, brain excision or sectioning, and with acquiring images on a fluorescence microscope, or clear interest in moving into imaging and histology as part of the role

• Mechanical or technical aptitude for maintaining and troubleshooting perfusion rigs and surgical setups

And you: • Are motivated by moonshot neuroscience and want to work on a high-impact project with a tight-knit team

• Are committed to open science and want to see the work disseminated transparently

We offer: • An opportunity to help change the world and work with some of the most talented and collaborative experts across scientific fields.

• An opportunity to gain experience on a field-defining moonshot effort.

• Excellent medical, dental, and vision insurance through a PPO plan; parental leave.

• Generous time off + paid holidays.

• 401K matching up to 6% of base salary

• Ample healthy and energizing food, including daily lunches.

• Stipend for fitness and wellness activities.